A NEW ANTINEOPLASTIC METHYLGERMANIUM(IV)PORPHYRIN

New ribonucleotide reductase inhibitors with antineoplastic activity.

possible cancer chemotherapeutic agents. Howeven, pre himinary data indicate that these compounds are toxic and are not effective in humans (4, 14). In order to develop an effective chemothemapeutic agent for which the mode of action is inhibition of nibonucleotide meductase activity, a number of ahiphatic and aromatic hydroxamic acids and their corresponding amides and esters were synthesized ...

Andrographolide: A New Plant-Derived Antineoplastic Entity on Horizon

Plant-derived natural products occupy an important position in the area of cancer chemotherapy. Molecules such as vincristine, vinblastine, paclitaxel, camptothecin derivatives, epipodophyllotoxin, and so forth, are invaluable contributions of nature to modern medicine. However, the quest to find out novel therapeutic compounds for cancer treatment and management is a never-ending venture; and ...

MicroRNA in cancer: New hopes for antineoplastic chemotherapy

MicroRNAs (miRNAs) are a class of endogenous non-coding small RNAs that are evolutionarily conserved and widely distributed among species. Their major function is to negatively regulate mRNA target genes, and miRNA expression has been found to be deregulated in all human cancers, where miRNAs play critical roles in tumorigenesis, functioning either as tumor suppressors or as oncogenes. This rev...

Mutagenicity experiments on agroclavines, new natural antineoplastic compounds.

Agroclavine, an alkaloid produced by some species of fungi and dicotyledon plants, and its 1-alkylated derivatives are potentially useful as antineoplastic drugs, since they exert potent and selective cytostatic effects. In the present study, we have investigated agroclavine and its 1-propyl and 1-pentyl derivatives for mutagenicity. The genetic end point studied was the reversion of strains of...

Antineoplastic Agents